Which are the best insulin-mimetic supplements?
Insulin-mimetic supplements are designed to mimic the actions of insulin in the body.
They’re believed to help promote the entry of glucose into tissues, regulate metabolic processes like gluconeogenesis and glycolysis, and activate signal proteins.
In this article, you’ll find a list of the best insulin-mimetic supplements on the market and answers to common questions around the benefits, side effects, and uses of insulin-mimetic supplements.
Here’s a list of the 10 best insulin-mimetic supplements.
Top 10 Insulin Mimetic Supplements Compared
Our supplement lists are created by researching the best-reviewed products from the most reputable companies and web sources.
In A Rush? Here’s Our Top Pick:
10. Jacked Factory – GDA XT
Jacked Factory GDA XT is designed to support insulin sensitivity to maximize muscle growth.
Each bottle contains 60 capsules, or 30 servings, all providing you with 300mcg of Chromium, 500mg of Berberine HCI, 400mg of GS4 (Gymnema Sylvestre Leaf Extract 25% Gymnemic Acids), 250mg of Cinnamon Bark Extract 4:1, 105mg of R-Alpha Lipoic Acid, 75mg of Banaba Leaf Extract, and 25mg of AstraGin (Astragalus Membranaceus & Panax Notoginseng Root Extract).
Other ingredients include Hypromellose and L-Leucine.
The brand suggests that GDA XT may enhance insulin sensitivity, muscle growth, glucose uptake, and fat loss.
Jacked Factory recommends taking two capsules 10-15 minutes before a high carbohydrate meal, up to two times a day for best results.
9. Metabolic Nutrition – Insulean
Metabolic Nutrition Insulean is an insulin-mimetic supplement formulated to improve insulin sensitivity, stabilize blood sugar levels, and increase muscle glycogen.
Each bottle contains 90 capsules, providing you with 30 servings of various vitamins, minerals, and Metabolic Nutrition’s Insulin Mimetic Matrix.
Other ingredients include Magnesium Silicate, Magnesium Stearate, Calcium Carbonate, Titanium Dioxide, Gelatin, Silicon Dioxide, and Stearic Acid.
The brand suggests that Insulean may help improve insulin sensitivity, maximize carbohydrate thermogenesis, reduce cravings, and promote all-day energy from carbs.
Metabolic Nutrition recommends taking one to two capsules per meal containing 30-60g of carbohydrates and upping it to two to three capsules for larger meals.
8. Aggressive Labz – SLIN-Z
Aggressive Labz SLIN-Z is formulated to improve glucose control and insulin sensitivity.
Each bottle contains 180 capsules, or 60 servings, all providing you with a premium blend of ingredients, including Chromium, Berberine, and Gymnema Sylvestre Powder.
Other ingredients include Magnesium Stearate, Rice Flour, and Gelatin.
The brand suggests that SLIN-Z may help assist with fat loss and lean muscle growth.
They also state that it will rapidly shuttle vital nutrients into your muscle cells, resulting in better muscle pumps, faster recovery times, and increased endurance.
Aggressive Labz recommends taking three capsules with a high carbohydrate meal twice a day for best results.
7. NuEthix Formulations – GDA-MAX+
NuEthix Formulations GDA-MAX+ is designed to support optimal blood glucose balance, muscle fullness, and vascularity.
Each bottle contains 90 capsules/servings, all providing you with a high-quality mix of ingredients, including Chromium, Berberine, Gymnema Sylvestre Leaf, and Green Tea Leaf Extract.
Other ingredients include Hypromellose, Vegetable Magnesium, Stearate, and Silica.
The brand suggests that taking GDA-MAX+ may help you partition nutrients more effectively, support insulin nutrition and glucose metabolism, achieve better muscle pumps and vascularity and boost your immune system.
NuEthix Formulations recommends taking one serving with carbohydrate-containing meals for best results and two servings with cheat meals to help improve nutrient partitioning.
6. Performax Labz – SLIN Max
Performax Labz SLIN Max is designed to maximize nutrient partitioning, increase blood flow, muscle growth, and insulin sensitivity.
Each bottle contains 120 capsules, providing you with 60 servings of the brand GDA Complex and Nutrient Partitioning Complex.
Main ingredients include Berberine, Banaba Extract, Cinnamon Bark Extract, and Chromium Picolinate.
Other ingredients include Gelatin, Silicon Dioxide, and Magnesium Stearate.
The brand suggests that SLIN Max may help regulate nutrient uptake, improve insulin action, shrink fat called, and increase insulin sensitivity overall.
The supplement is made in the USA in a cGMP-compliant facility and tested to ensure purity and potency.
Performax Labz recommends taking two capsules 30 minutes before meals containing 50g of carbohydrates for best results.
5. Condemned Labz – HumaSLIN
Condemned Labz HumaSLIN is formulated to help optimize insulin, stabilize glucose, and boost nutrient shuttling.
Each bottle contains 60 capsules, providing you with 30 servings of high-quality insulin-mimetic ingredients.
Main ingredients include Cinnamon Bark, Gymnema Extract, Fenugreek Extract, Chromium Picolinate, and Banaba Corsolic Acid.
Other ingredients include gelatin, rice flour, magnesium stearate, and silicon dioxide.
The brand suggests that HumaSLIN may help improve glucose disposal and utilization, increase nutrient partitioning, combat fat storage, enhance glycogen replenishment, and promote muscle fullness.
Condemned Labz recommends taking two capsules with meals containing at least 50 grams of carbohydrates before and after a workout for best results.
4. Enhanced Athlete – SLIN
Enhanced Athlete SLIN is an insulin-mimetic supplement designed to increase muscle insulin sensitivity, improve performance, and reduce body fat.
Each bottle contains 120 capsules, or 40 servings, all providing you with 300mg of Berberine, 200mg of Cinnamin Extract 30:1, 150mg of ALA, 150mg of Fenugreek, 150mg of Kaempferol, 90mg of Myricetin, 50mg of Irvingia Gabonensis, and 8mg of Fucoxanthin.
Other ingredients include Gelatin, Maltodextrin, and Silica.
The brand suggests that SLIN may help shuttle carbs into your muscles, partition fat storage, lower insulin levels, enhance fat loss, and increase muscle pumps.
Enhanced Athlete recommends taking three capsules with your highest carb meals for best results.
3. Magnum Nutraceuticals – Mimic
Magnum Nutraceuticals Mimic is designed to increase insulin sensitivity and reduce carbs stored as fat.
Each box contains 60 capsules, providing you with 30 servings of premium ingredients.
The main ingredients include 207mg of Jiaogulan, 200mg of Berberine, 200mg of R+ Alpha Lipoic Acid, 200mg of Cinnamomum Cassia 8:1, and 400mcg of Chromium 454.
Other ingredients include Cellulose, Silicon Dioxide, Magnesium Stearate, and Gelatin.
By supplementing with Mimic, the brand suggests that it may help improve carbohydrate utilization, promote bigger, fuller pumps and vascularity, and drive amino acids and creatine uptake into your muscles more efficiently.
Magnum Nutraceuticals recommends taking one or two capsules approximately fifteen minutes before your post-workout meal or with your largest meal of the day for best results.
2. Rich Piana 5% Nutrition – Freak Show
Freak Show is formulated to mimic the power of insulin without the negative downside.
Each bottle contains 180 capsules, all providing you with potent ingredients that work together to increase insulin sensitivity.
The brand suggests that using Freak Show may help optimize hormone insulin to prevent fat storage, control glucose levels, transport fat to muscles, refill your glycogen stores, and boost overall performance and recovery.
They also state that Freak Show is perfect for individuals on a high-carb diet looking to pack on size and strength.
Rich Piana 5% Nutrition recommends taking one serving 15-20 minutes before your highest carbohydrate meal of the day for best results.
1. Huge Nutrition – Utilize
Utilize, by Huge Nutrition is designed to increase nutrient uptake and support healthy metabolic function.
Each bottle contains 180 capsules or 30 servings.
Main ingredients include Vitamin D3, Magnesium, Chromium, Berberine HCL, Bitter Melon Extract, Cinnamon Powder, Alpha Lipoic Acid, Gymnema Sylvestre Extract, Fenugreek, and Cinnulin PF Cinnamon Bark Extract.
Other ingredients include Vegetable Cellulose, Rice Fiber, Silicon Dioxide, and Magnesium Stearate.
The brand suggests supplementing with Utilize may help shuttle carbohydrates directly into your muscles instead of fat cells, burn fat, and build lean muscle.
They also state that Utilize has been proven to maintain healthy metabolism levels, resulting in higher insulin sensitivity.
The supplement is manufactured in the USA following Good Manufacturing Practices (GMP) and thoroughly tested to ensure purity and potency.
Huge Nutrition recommends taking three capsules in the morning and three capsules in the evening with high carbohydrate meals for best results.
Frequently Asked Questions About Insulin Mimetic Supplements
Q: What Are Insulin Mimetic Supplements?
Insulin mimetic supplements contain ingredients that mimic the actions of insulin in the body.
These include promoting the entry of glucose into tissues, activating signal proteins, and regulating metabolic processes such as gluconeogenesis, fatty acid synthesis, glycolysis, and the pentose phosphate pathway.
The most common natural ingredients found in insulin mimetic supplements include Berberine, Cinnamon, Alpha Lipoic Acid (ALA), Fenugreek, and Fucoxanthin.
Q: What Are The Benefits of Insulin Mimetic Supplements?
Insulin regulates glucose metabolism and supports fat metabolism in the body.
The main benefit of using insulin-mimetic supplements is to increase levels of insulin in your body, which can help the body use excess glucose efficiently instead of storing it as fat.
Insulin mimetic supplements help fuel and restore muscle cells with the nutrients they need to grow.
Other known benefits include lowering blood sugar levels, improving cholesterol levels, improving insulin sensitivity, and supporting weight loss.
Q: Do Insulin Mimetic Supplements Have Any Side Effects?
Currently, there is not enough research to determine whether or not insulin-mimetic supplements have any side effects.
We suggest talking to your doctor or a healthcare professional before adding any of the supplements included in this roundup to your diet.
Q: How Do I Take Insulin Mimetic Supplements?
Most brands recommend taking insulin-mimetic supplements with your highest carbohydrate meal of the day, either pre or post-workout.
Capsuels are the most common form of insulin-mimetic supplement due to their convenience, so we suggest following the manufacturers’ recommended serving guidelines and assessing your tolerance as you go.
Q: Which Insulin Mimetic Supplement Should I Choose?
We suggest choosing a supplement manufactured in an FDA-registered, GMP-compliant facility that contains as many natural ingredients as possible.
You should also look for a supplement that has been tested and certified by a third party, and that lists the individual ingredient amounts on the Supplement Facts label, so you know exactly what you’re getting.
We hope you enjoyed our list of the 10 best insulin-mimetic supplements.
If you’d like to learn more about other beneficial supplements, check out our latest guides.
Here’s a quick recap of the 10 best insulin-mimetic supplements:
- Huge Nutrition – Utilize
- Rich Piana 5% Nutrition – Freak Show
- Magnum Nutraceuticals – Mimic
- Enhanced Athlete – SLIN
- Condemned Labz – HumaSLIN
- Performax Labz – SLIN Max
- NuEthix Formulations – GDA-Max+
- Aggressive Labz – SLIN-Z
- Metabolic Nutrition – Insulean
- Jacked Factory – GDA XT