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The 10 Best 5-HTP Supplements




The Best 5-HTP Supplements to Buy

Which are the best 5-HTP supplements?

5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid in the human body. 

Its purpose is to increase serotonin levels, which affect sleep, appetite, body temperature, and pain sensation. 

Therefore, using a 5-HTP supplement to increase serotonin levels has been shown to boost cognitive function, speed up weight loss, and improve overall well-being. 

So, with that in mind, we’ve rounded up the best 5-HTP supplements on the market to help you choose the one best suited for you.

Here’s a list of the 10 best 5-HTP supplements:


The 10 Best 5-HTP Supplements

The list of 5-HTP supplements and figures mentioned below has been compiled from various web sources.

These are the 10 best 5-HTP supplements:


10. Jarrow Formulas – 5-HTP

Jarrow Formulas 5-HTP 50mg, Brain and Memory Support, 90 Caps
  • 5-Hydroxytryptophan Capsules
  • May Be Useful In Promoting Mental Health (as a...
  • Melatonin Precursor: May Promote Sleep

Jarrow Formulas 5-HTP supports cognitive brain function and mental health. 

You’ll receive 90 capsules/servings per bottle, each containing 50mg of pure 5-Hydroxytryptophan.

The brand suggests that their supplement may help promote a better night’s sleep as it’s a precursor to melatonin. It may also benefit overall mental health as it acts as a precursor to serotonin. 

The supplement is 100% gluten-free and includes ingredients like Cellulose, Magnesium Stearate, Silicon Dioxide, and Gelatin. 

Jarrow Formulas recommend taking one capsule a day on an empty stomach for best results.


9. Doctor’s Best – 5-HTP

Doctor's Best 5-HTP Enhanced with Vitamins B6 & C, Non-GMO, Vegan, Gluten Free, Soy Free, 120 Veggie Caps
  • Doctor's Best 5-HTP enhanced with Vitamins B6 and C...
  • 5-HTP aids serotonin production; Serotonin is the...
  • Synthesis of serotonin in the brain requires an...

Doctor’s Best 5-HTP is enhanced with vitamin B6 and C to help support sleep, mood, anxiety, and stress. 

Each bottle comes with 120 capsules/servings, all containing 100mg of 5-Hydroxytryptophan, 200mg of Vitamin C, and 15mg of Vitamin B6. 

Doctor’s Best suggests that using 5-HTP regularly may help you maintain mental and emotional well-being and promote healthy sleep due to its support of serotonin production. 

The supplement is Non-GMO, gluten-free, and vegan, and is extracted from the Griffonia Simplicifollia plant’s seeds.

For best results, the brand recommends taking one capsule a day, with or without food. 


8. SmarterVitamins – 5-HTP

200mg 5-HTP + Vitamin B6 & Hemp Oil for Ultra Serotonin Supplement Support + Natural Stress Relaxation, Mood & Sleep Boost, Extra Strength Extended Time Release
  • 5HTP is a Natural Sleep Aid Mood Enhancing Supplement...
  • Easily Absorbed 100mg Berry Softgels. Smarter 5HTP is...
  • Smarter 5-HTP is enhanced with Vitamin B6 & Hemp Seed...

SmarterVitamins 5-HTP contains vitamin B6 and hemp oil to catalyze the conversion of 5-HTP to serotonin. 

Per bottle, you’ll receive 60 liquid softgels, providing you with 30 servings if you stick to the recommended guidelines of two softgels a day. 

Each serving contains 200mg of 5-HTP, 200mg of Hemp Seed Oil, and 13.6mg of Vitamin B6. 

SmarterVitamins 5-HTP is made in the U.S.A and is 100% free from artificial fillers, preservatives, gluten, wheat, lactose, and more.

To get the most out of the supplement, the brand suggests taking two liquid softgels daily with a meal consistently. 


7. Natrol – 5-HTP

Natrol 5-HTP Time Release tablets, Promotes a Calm Relaxed Mood, Helps Maintain a Positive Outlook, Enables Production of Serotonin, Drug-Free, Controlled Release, Maximum Strength, 200mg, 60 Count
  • PROMOTES RELAXATION - Natrol 5-HTP is a 100% drug-free...
  • HELP PROMOTE BETTER SLEEP - 5-HTP is naturally...
  • CONTROL APPETITE - Regular use of Natrol 5-HTP may help...

Natrol 5-HTP is a time-released 5-HTP supplement that promotes a calm and relaxed mood. 

You’ll receive 60 tablets/servings per bottle, each containing 200mg of 5-Hydroxytryptophan, and 55mg of Calcium. 

Natrol suggests that you may experience benefits ranging from a calm and relaxed mood, better sleep, and greater control over your appetite by using their supplement regularly. 

It’s 100% drug-free and does not contain any artificial flavors, colors, or preservatives.

Natrol recommends taking one tablet a day with food for the best results. 


6. Toniiq – 5-HTP

Ultra High Strength 5HTP Capsules - 99%+ Pharmaceutical Grade - 12:1 Concentrated Extract - The Highest Purity 5 HTP Available for Optimal Serotonin and Sleep Support - 200mg - 90 Veggie Capsules
  • The most active form of 5-HTP: Toniiq 5-HTP capsules...
  • A key active ingredient: 5-HTP has amazing health...
  • Setting a new standard for purity: To ensure that you...

Toniiq 5-HTP ultra high strength capsules contain pharmaceutical grade 5-HTP of the highest purity. 

Inside each tub, you’ll receive 90 capsules/servings, all containing 200mg of 5-Hydroxytryptophan. 

Toniiq supplements are produced in a GMP-certified state-of-the-art manufacturing facility in Miami, U.S.A, free from artificial preservatives, wheat, and gluten.

The brand suggests that you may experience better sleep, less anxiety, greater control over your appetite, and a boost in your overall mood when taking 5-HTP regularly. 

To get the most out of the supplement, Tonniq recommends taking one capsule per day with a meal. 


5. NatureWise – 5-HTP

NatureWise 5-HTP Max Potency 200mg | Mood Support, Natural Sleep Aid & Helps Curb Appetite | Delayed Release Capsules Easy on The Stomach | Enhanced w/ Vitamin B6 | Non-GMO [2 Month Supply - 60 Count]
  • MAXIMUM POTENCY FORMULA: NatureWise 5-HTP Plus+...
  • EASY MONEY BACK GUARANTEE: 5-HTP isn’t for everyone....

5-Hydroxytryptophan by NatureWise utilizes delayed-release capsules that are enhanced with vitamin B6 for better absorption. 

You’ll receive 60 capsules/servings per bottle, each containing 200mg of 5-HTP and 5mg of vitamin B6. 

The delayed-release capsules help minimize stomach discomfort, which can occur when 5-HTP is taken in high doses. 

NatureWise suggests that using their supplement regularly can improve stress levels and hunger cravings and promote healthy sleep patterns. 

For best results, the brand recommends taking one capsule per day with food, depending on your schedule.


4. Nutricost – 5-HTP

Nutricost 5-HTP 100mg, 240 Capsules (5-Hydroxytryptophan) - Vegetarian Capsules, Gluten Free, Non-GMO
  • 240 Vegetarian Capsules of High Quality 5-HTP
  • 100mg of 5-HTP Per Capsule
  • Vegetarian Friendly, Non-GMO, Gluten Free

Nutricost 5-HTP capsules are non-GMO, gluten-free, and vegan friendly. 

Each capsule contains 100mg of pure 5-Hydroxytryptophan, and you’ll receive 240 capsules/servings per bottle. 

All Nutricost’s supplements are manufactured in a GMP compliant, FDA Registered facility and are third-party tested for purity and uniformity. 

According to the brand, when taken consistently, you may notice a positive impact on your energy, stress, and anxiety levels, as well as your emotional well-being.

NatureWise recommends taking one capsule a day, preferably on an empty stomach with water, to get the most benefit from the supplement.


3. NOW Supplements – 5-HTP

NOW Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support, 120 Veg Capsules

NOW Foods 5-HTP is best used to support a positive mood and relaxation. 

Each capsule contains 100mg of 5-Hydroxytryptophan, and you’ll receive 120 capsules/servings per bottle. 

NOW Foods indicates that 5-HTP supports serotonin production in the brain, and therefore you may experience higher quality sleep, a better overall mood and appetite.

The supplement is GMP quality assured and vegan friendly. 

The brand recommends taking one capsule per day for best results, preferably on an empty stomach at night. 


2. Arazo Nutrition – 5-HTP

5-HTP 200mg Plus Calcium for Mood, Sleep, Anxiety - Boosts Serotonin Production - 99% High Purity – 120 Capsules – Arazo Nutrition
  • Extra High 99% Purity – Super potent at 99% purity,...
  • Calcium Enhanced Super Formula – The extra 328mg of...
  • Highest Standard: Trusted for ingredient safety,...

5-HTP by Arazo Nutrition is enhanced with Calcium to intensify deeper and more restful sleep. 

Each bottle comes with 120 capsules/servings, all containing 200mg of pure 5-HTP and 328mg of Calcium. 

Arazo Nutrition suggests that you may feel happier, less stressed, and overwhelmed, and may fall asleep easier by taking 5-HTP consistently for prolonged periods.

All the brands’ supplements are made in a GMP certified facility in America and are third party safety tested for purity. 

Arazo Nutrition recommends taking two capsules once per day, ideally in the morning with your first meal, along with 8oz of water for best results. 


1. Dr. Emil Nutrition – 5-HTP Plus

200 MG 5-HTP Plus Serotonin Synthesizers and Cofactor B6 for Improved Serotonin Conversion - Enhanced 5HTP Supplement for Serotonin Boost, Mood and Sleep Support
  • 5-HTP enhanced super formula - We supplemented 200mg of...
  • B6 for improved serotonin conversion - Our formula...
  • Mood, anxiety & sleep support - 5-HTP is the primary...

Dr. Emil Nutrition 5-HTP Plus contains additional cofactors for improved serotonin conversion.

Inside each bottle, you’ll receive 60 capsules, providing you with a 30 day supply if you follow the brand’s recommended serving guidelines. 

Each serving gives you 200mg of 5-Hydroxytryptophan, as well as 20mg of L-Tryptophan, 20mg of SAMe, and 10mg of vitamin B6. 

By taking their supplement regularly, the brands suggest that you may feel less anxious, sleep better, and have a better mood due to the 5-HTP increasing your body’s natural serotonin levels.

Dr. Email Nutrition recommends taking two capsules once a day accompanied by at least 8oz of water for best results. 



We hope you enjoyed our list of the 10 best 5-HTP supplements.

As you’ve just seen, there are many great supplements to choose from when it comes to 5-HTP; each offering something slightly different from the other.

So, if you’re looking for our recommendation, we chose to go with Dr. Emil Nutritons 5-HTP Plus as it was the best all-around supplement for what we needed and had thousands of positive reviews. 

If you enjoyed this, check out:

Here’s a quick recap of the 10 best 5-HTP supplements:

  1. Dr. Emil Nutrition – 5-HTP Plus
  2. Arazo Nutrition – 5-HTP
  3. NOW Supplements – 5-HTP
  4. Nutricost – 5-HTP
  5. NatureWise – 5-HTP
  6. Toniiq – 5-HTP
  7. Natrol – 5-HTP
  8. SmarterVitamins – 5-HTP
  9. Doctor’s Best – 5-HTP
  10. Jarrow Formulas – 5-HTP

What’s your favorite 5-HTP supplement? Leave a comment below.

Matt is a certified digital marketing and SEO consultant who's passionate about health and fitness. With almost two decades of lifting experience under his belt, Matt shares his knowledge and expertise with us around bodybuilding and supplementation. Deadlifts and barbell curls are his go-to exercises, and, when he's not writing about health and fitness, you'll find him in the gym busting out some arms!

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