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The 10 Best SAM-e Supplements to Buy




The Best Sam-e Supplements to Buy

Which are the best SAM-e supplements?

SAM-e, or S-Andenosyl Methionine, is a naturally occurring compound in the body. 

In a nutshell, it helps produce and regulate hormones and maintain cell membranes. 

Research has shown that supplementing with SAM-e can help with depression, osteoarthritis, and liver disease.

In this article, we’ve rounded up the best SAM-e supplements to help you identify which one might be right for you. 

So, without further ado, here’s a list of the 10 best SAM-e supplements:


The 10 Best SAM-e Supplements

The list of SAM-e supplements and figures mentioned below has been compiled from various web sources.

These are the 10 best SAM-e supplements:


10. Life Extension SAM-e

Life Extension Same S-Adenosyl-Methionine 400 Mg, 60 Enteric Coated Tablets
  • Helps maintain stable mood
  • Helps maintain liver health
  • Helps maintain healthy joint function

Life Extension’s SAM-e supports joint pain, liver health, and overall well-being. 

Each bottle provides you with 60 enteric-coated tablets containing 400mg of pure S-Andenosyl Methionine. 

Some additional benefits include mood stabilization and glutathione production, one of the body’s most important antioxidants.

For best results, Life Extension recommends taking one to three tablets daily, preferably with a meal, and to consume with co-factors like vitamin B12, B6, and folic acid. 


9. Healthy Way Pure SAM-e

Healthy Way Pure SAM-e 500mg 90 Capsules (S-Adenosyl Methionine) Supports Joint Health & Brain Function - NON-GMO USA Made 100% Money Back Guarantee - Order Risk Free!
  • About Sam-E GUARANTEE HIGH QUALITY: We ensure that...

Healthy Way Pure SAM-e supports joint health, brain function and may help to detoxify the liver. 

You’ll receive 90 capsules per bottle, each containing 500mg of pure SAM-e powder. 

The capsules are 100% natural, Non-GMO, independently tested, certified organic, and made in the U.S.A.

Healthy Way suggests that taking SAM-e can help the body increase its glutathione production, resulting in a boost of antioxidants that fight against free radicals. 

To get the most bang for your buck, the brand suggests that Pure SAM-e can help replenish SAM-e levels in the body and restore a healthy mood when taken daily. 


8. Nasa Beahava Pure SAM-e

NASA BEAHAVA Pure SAM-e 500mg 90 Capsules (S-Adenosyl Methionine) Supports Joint Health and Brain Function
  • About Sam-E GUARANTEE HIGH QUALITY: We ensure that...
  • MAY IMPROVE MOOD AND WELL-BEING Researches over the...

Nasa Beahava’s maximum strength SAM-e supplement offers users 500mg of pure S-Adensoyl-Methionine per serving. 

Each bottle provides you with 90 capsules/servings free from artificial colors and flavors, lactose, and gluten.  

Nasa Beahava suggests that by supplementing with SAM-e, you may experience improved brain function, joint and liver health, and improvements in your mood and well-being. 

Additional benefits include cellular growth and repair, increased regulation of Seratonin, Norepinephrine, Dopamine, less anxiety, and enhanced energy levels.

To maximize the benefits, the brand recommends taking one serving per day with a meal and monitoring the results before increasing the dose. 


7. aSquared Nutrition Pure SAM-e

SAM-e 400mg Supplement - 90 Capsules - Same (S-Adenosyl Methionine) to Support Mood, Joint Health, and Brain Function - Extra Strength Vegan SAM e Pills
  • MAXIMUM STRENGTH SAM-e: 400mg of SAM-e per capsule, and...
  • SUPPORTS HEALTHY MOOD: SAM-e promotes healthy brain...
  • PROMOTES BRAIN HEALTH: Supports cognitive function, and...

Pure SAM-e by aSquared Nutrition supports anti-aging, mental performance, joint, and liver health. 

You’ll receive 90 capsules/servings per bottle, each containing 400mg of pure SAM-e powder. 

The capsules are free from preservatives, soy, dairy, and gluten and are manufactured in an FDA registered and GMP compliant facility in the U.S.A. 

By taking their SAM-e supplement, aSquared Nutrition suggests that you may see benefits ranging from healthy brain function to cellular growth and repair, as well as increases in mood, well-being, and energy.

For best results, aSquared Nutrition recommends taking one to two capsules per day with a meal and not exceeding a maximum of two capsules within 24 hours. 


6. Pure Encapsulations SAM-e

Pure Encapsulations - Same (S-Adenosylmethionine) - Hypoallergenic Supplement to Support Positive Mood and Cognitive Function - 60 Capsules
  • Overall Health: Provides support for positive mood,...
  • Positive Mood: SAMe promotes positive mood and...
  • Joint Health: SAMe supports joint comfort and function...

Pure Encapsulations SAM-e is designed to support cognitive function, joint comfort, and healthy cell growth.

Each serving/capsule contains 200mg of S-Adensoyl-Methionine, and you’ll receive 60 servings per bottle if you follow the recommended serving guidelines. 

The capsules are gluten-free, Non-GMO, vegan, and tested and certified to verify potency and purity.

According to the brand, you may experience positive cognitive function, joint pain relief, improvements in mood and well-being, and enhanced energy levels.

Pure Encapsulations recommends taking one to two capsules daily, between meals, but assessing your tolerance with one capsule, to begin with.  


5. NOW Supplements SAM-e

NOW Supplements, SAMe (S-Adenosyl-L-Methionine)200 mg, Nervous System Support*, 120 Veg Capsules
  • Stabilized SAMe, Capsule Form
  • No Enteric Coating Needed
  • Supports Joint Health*

NOW Supplement’s SAM-e offers 200mg of stabilized S-Adensoyl-Methionine per capsule and 120 servings/capsules per bottle. 

The brand suggests taking one capsule two to four times daily, preferably on an empty stomach.

As a result, you may see improvements in joint pain relief, energy, and cognitive performance.

The SAM-e capsules are manufactured without wheat, gluten, soy, milk, egg, fish, or tree nut ingredients and are produced in a GMP compliant facility.

Other ingredients include Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, and Stearic Acid.


4. Jarrow Formulas SAM-e

Jarrow Formulas Sam-e, Promotes Joint Strength, Liver Detoxification, 200mg, 20 Tabs
  • Promotes: Longevity Joint Strength Liver Detoxification...
  • Enteric-Coated Pharmaceutical Grade SAMe
  • Central biochemical building block

Jarrow Formulas SAM-e helps promote liver detoxification, joint strength, and positive brain function. 

You’ll receive 20 servings/tablets per bottle, each containing 200mg of pure S-Adensoyl-Methionine.

The capsules are gluten-free, certified vegan, and designed to increase mood, energy, and cognitive performance, without any side effects.  

For best results, Jarrow Formulas recommends taking one to two tablets per day on an empty stomach but starting with one tablet until you’ve assessed your tolerance. 


3. Nature’s Trove SAM-e

SAM-e 400mg by Nature's Trove - 90 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Promotes Positive Mood and Joint Comfort - Cold Form Blister Packed.
  • PREMIUM QUALITY: Nature's Trove is committed to making...
  • EXPERTISE & INDUSTRY LEADERSHIP: Our experts have been...
  • MOOD AND WELLBEING: Are you experiencing: sadness,...

Nature’s Trove SAM-e is certified vegan, kosher, Non-GMO, and gluten-free. 

It offers 400mg of SAM-e per serving, and each bottle comes with a 90 day supply, provided you stick to the recommended serving guidelines. 

According to the brand, SAM-e has been clinically shown to maintain a healthy mood, support emotional well-being, boost serotonin and dopamine, and work as an effective anti-depressant. 

By taking SAM-e, Nature’s Trove suggests that it might enhance mobility and flexibility, improve cartilage production, and support overall joint health.

Nature’s Trove recommends taking one caplet daily, preferably on an empty stomach, for best results.


2. Nature Made SAM-e Complete

Nature Made SAM-e is designed to help support a healthy mood and well-being in as little as 7-14 days. 

Each bottle provides you with a 60 day supply, with a recommended serving size of one 400mg tablet per day.

Some of the main benefits you can expect to see by taking Nature Made SAM-e include improvements in mood and cognitive ability, reductions in joint pain, and the support of a healthy liver. 

Nature Made recommends adults start by taking one tablet a day with water on an empty stomach and assessing tolerance over two weeks.

If you don’t experience any benefits within two weeks, you may need to increase the supplementation level by gradually raising the number of tablets until you notice results. 


1. Doctor’s Best SAM-e

Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets
  • Doctor's Best SAMe Double Strength is proven to enhance...
  • SAMe is essential for the healthy metabolism of the...
  • SAMe has been proven to promote joint comfort and...

Doctor’s Best SAM-e is proven to promote cognitive health while simultaneously enhancing your mood. 

You’ll receive 60 tablets/servings per bottle, each containing 400mg of pure SAM-e powder.

The brand suggests that their supplement has been proven to promote joint comfort, mobility, liver health, and detoxification. 

All capsules are Non-GMO, gluten-free, vegan, and are manufactured in a cGMP certified facility. 

Doctor’s Best recommends taking one tablet a day in between meals for best results. 



We hope you enjoyed our list of the 10 best SAM-e supplements.

We’ve been using Doctor’s Best SAM-e for a while and can honestly say that it makes a big difference when it comes to joint pain relief and cognitive performance. 

So if you’re thinking about trying SAM-e, we recommend trying Doctor’s Best SAM-e. 

If you enjoyed this, check out:

Here’s a quick recap of the 10 best SAM-e supplements:

  1. Doctor’s Best SAM-e
  2. Nature Made SAM-e Complete
  3. Nature’s Trove SAM-e
  4. Jarrow Formulas SAM-e
  5. NOW Supplements SAM-e
  6. Pure Encapsulations SAM-e
  7. aSqaured Nutrition Pure SAM-e
  8. Nasa Beahava Pure SAM-e
  9. Healthy Way Pure SAM-e
  10. Life Extension SAM-e

What’s your favorite SAM-e supplement? Leave a comment below.

Matt is a certified digital marketing and SEO consultant who's passionate about health and fitness. With almost two decades of lifting experience under his belt, Matt shares his knowledge and expertise with us around bodybuilding and supplementation. Deadlifts and barbell curls are his go-to exercises, and, when he's not writing about health and fitness, you'll find him in the gym busting out some arms!

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